Endocrine Abstracts

Pituitary carcinomas are rare but represent a particular challenge to clinical practice. We report a case of pituitary carcinoma with metastatic disease in a separate non-contiguous foci within the central nervous system. A 64 year old man presented with a large non-functioning pituitary adenoma manifesting as headache, third pair of cranial nerves paralysis, panhypopituitarism and impaired visual acuity in 1996.The tumour was grossly removed through a right pterional cranioto...

Introduction: In Graves’ hyperthyroidism with long-term antithyroid drugs (ATD) treatment, remission is often umpredictable. However variables at diagnosis or at the end of the ATD regimen are associated with a highest likelihood of recurrence and could be used to decide an ablative treatment.Objective: To identify variables before and at the end of a long-term treatment with ATD (>6 months) associated with higher rates of relapse during a follo...

Introduction: Vitamin D deficiency is very common in our population.It is not clear which is the most effective vitamin D dosing regimen in patients with deficiency.Objective: To compare two vitamin D supplementation regimen in patients with vitamin D deficiency.Material and methods: This is an interventional study: Patients atended in our clinic during May and June 2017 with 25-Hydroxyvitamin D below 30 ng/ml were consecutively se...

Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It has been defined by an absence of overt Cushing’s syndrome (CS) signs (no skin weakness, muscle atrophy, or osteoporosis) associated with biological hypercortisolism consisting of high urinary free cortisol (UFC) and an absence of negative feedback loop of cortisol on HPA, defined as 8-AM cortisol level >50 n...

Kiss1 neurons are essential elements in the central pathways controlling the reproductive axis. In rodents, two major hypothalamic populations of Kiss1 neurons exist, in the arcuate nucleus (ARC) and in the rostral periventricular area of the third ventricle (RP3V). The majority of ARC Kiss1 neurons express two others neuropeptides, neurokinin B (NKB; encoded by Tac2) and dynorphin (Dyn); hence, this population has been named KNDy. Yet, NKB-only and Kiss1-only neurons are also...

Introduction: There are a few hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant (pseudomalbsortion), or where there is the possibility of excipient-induced disease exacerbation, therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients is to es...

Introduction: Doege-Potter syndrome (DPS) is a rare paraneoplastic syndrome consistent in non-islet-cell tumor hypoglycemia associated with solitary fibrous tumor (SFT). Pathogenesis of hypoglycemia has been attributed to the production of insulin-like growth-factor-2 (IGF-2) by tumor cells. We report two DPS patients with metastatic extrapleural SFT.Case 1: A 42-year-old man with SFT of the mesocolon that had been operated in 2010, presented with metast...

Aim: To describe the follow-up of adrenal incidentalomas (AI) classified as non-functioning and no suspicious for malignancy in the first approach.Patients and methods: Observational retrospective study of a cohort of patients who consulted in the Endocrinology service between 2005 and 2015 because of an AI. Statistical analysis performed with SPSS 19th version.Results: Two hundred and one patients with IA were firstly evaluated. T...

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

Introduction: Calcitriol-mediated hypercalcemia is one of the most common paraneoplastic syndromes associated with lymphoma.Aim: Evaluate clinical and biochemical manifestations as well on the management of hypercalcemia in patients with lymphoma.Materials and methods: Prospective analysis of patients with lymphoma who developed hypercalcemia during September-2011 and January-2016.Results: Two hundred and six...